If you’re developing games in any space or developing anything in the mobile space you’re going to have to be concerned about memory management. A lot. It doesn’t matter if you’re doing it manually, reference counting, using ARC or garbage collection. If you’re pushing the envelope in any way the details of how memory is managed matter greatly. In Unity 3D the C# garbage collection is one of those details, and there’s very few articles which deal with it specifically. Wendelin Reich just changed that:

I learned the hard way that in game development, you cannot rely on automatic memory management.

Wendelin Reich’s C# Memory Management for Unity Developers